Maternal undernutrition concerns 10-19% of women of reproductive age globally, the vast majority of which live in sub Saharan Africa and south Asia. Recommendations for nutritional interventions to tackle the problem range from per-pregnancy supplementation to upstream interventions targeting women of reproductive age before conception. To render the latter interventions cost-effective and sustainable, experts recommend to focus on food processing that leads to an enhanced nutrient content. One such method, which has been known and practiced for centuries in diverse societies, is fermentation. Traditionally fermented foods are diverse, widespread and highly appreciated in Burkina Faso. The present study aims to investigate the effect of fermented millet porridge on gut microbiota diversity, stool short chain fatty acid concentration and inflammation markers level in women of reproductive age living in rural Burkina Faso.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
80
A millet porridge (fermented or not, depending on group allocation) serving will be provided to participants daily, for consumption. consumption will be directly observed.
IRSS-DRO
Bobo-Dioulasso, Houet, Région Des hauts-Bassins, Burkina Faso
RECRUITINGGut microbiota diversity
gut microbiota alpha and beta diversity
Time frame: 0 to 13 weeks
Concentration of inflammation markers in blood and stool
Concentration of IL1-beta, IL 8, IL 6, IL 33, TNF-alpha, lipocalin 2, myeloperoxidase, calprotectin
Time frame: 0 to 13 weeks
Concentration of short chain fatty acid in stool
Concentration of C2-C8 fatty acids in stool
Time frame: 0 to 13 weeks
concentration of macronutrients in millet dough and porridge
Levels of carbohydrates, lipids, protein, dietary fiber and phytates
Time frame: 2 to 8 weeks
relative abundance of bacterial and fugal micro-organisms in millet dough and porridge
Count of microbial populations
Time frame: 2 to 8 weeks
Concentration of Ferritin in plasma
Ferritin levels in Plasma
Time frame: 0- to 13 weeks
Number of participant with anemia
hemoglobin concentration in grams per deciliter
Time frame: 0 to 13 weeks
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