Evaluation of the Anti-aging Efficacy of a Novel Skin Health Product

Inclusion Criteria: * Written Informed Consent to participate in the study * Willingness to actively participate in the study and to come to the scheduled visits * Female * From 50 to 75 years of age * Visible wrinkle in the face (grade 3 to 6 according to proderm scale) see Appendix 2 * Healthy skin in the test areas * Vaccination of tetanus within the last 10 years (for biopsy sub group) Exclusion Criteria: * Female subjects: Pregnancy or lactation * Drug addicts, alcoholics * AIDS, HIV-positive or infectious hepatitis * Conditions which exclude a participation or might influence the test reaction/evaluation * Participation or being in the waiting period after participation in cosmetic and/or pharmaceutical studies pertaining to the test area * Cancer not being diagnosed as cured and requiring chemotherapy, irradiation and/or hormonal treatment within the last 2 years * Diabetes mellitus (type 1 and 2) * One of the following illnesses with reduced physical capability/fitness: asthma (symptom-free allergic asthma is not an exclusion criterion), hypertension, cardiovascular diseases * Documented allergies to cosmetic products and/or ingredients, skin care and/or skin cleansing products * Intolerability against adhesive dressing (e.g. acrylate) * Active skin disease at the test area * Regular use of tanning beds * Wounds, moles, tattoos, scars, irritated skin, excessive hair growth, etc. at the test area that could influence the investigation * Any topical medication at the test area within the last 3 days prior to the start of the study * Medical treatment for wrinkle reduction (e.g. peeling with vitamin A or fruit acids) on the face within the last 2 weeks prior to the start of the study * Systemic therapy with immuno-suppressive drugs (e.g. corticosteroids) and/or antihistamines (e.g. antiallergics) within the last 7 days prior to the start of the study * Systemic therapy with anti-phlogistic agents or analgetics (e.g. diclophenac), except for minor pain relief medicine like paracetamol within the last 3 days prior to the start of the study * Therapy with antibiotics within the last 2 weeks prior to the start of the study * Regular medication with anti-coagulating drugs like Aspirin®, Macumar®, etc. (e.g. for thrombosis prophylaxis) within up to 15 days prior to the taking of the biopsies * Past cosmetic surgery procedure in the test area (e.g. laser, facelift) * History of complications at wound healing (e.g. keloids, hypertrophic scars or contracture scar)