Breast MRI in Evaluation of Pathologic Response in Patients With Breast Cancer With Neoadjuvent Chemotherapy

Inclusion Criteria: * all women referred to the radiology department for breast MRI examination either for screening, evaluation of suspicious lesions onsono-mammography \\ * Patients with locally advanced breast cancer * Patients with early stage breast cancer and chemo-responsive tumour markers (i.e. triple negative, Her2+), who will benefit from downsizing for breast conserving surgery (BCS) * Absolute or Relative contraindications to surgery (advanced age/multiple medical comorbidities) in the setting of estrogen receptor positive tumours (for consideration of neoadjuvant endocrine therapy)3 * Patients must be elder than 18 years old. * patients with accepted renal function Exclusion Criteria: * Patients with metastatic breast cancer. * Patient with breast mass more than 5 cm . * Patients with fungating breast mass . * Patients with stage IV \[tumor spread to chest wall and to skin \]. * pregnant women especially in 1th trimester. * Patient with presence of any paramagnetic substance as pacemakers. * severely ill patients . * patients with claustrophobia. * arrhythmic patients