This study will be done to investigate the feasibility and effectiveness of a 24-week multidomain intervention program consisting of cognitive training, exercise, nutrition management, vascular disease risk factor management, and motivational enhancement on the cognitive function via none-face-to-face platform in mild cognitive impairment.
The physical exercise program will consist of aerobic exercise, exercise to enhance balance and flexibility, muscle-strengthening activities involving major muscle groups, and finger-toe movements. Cognitive training targets the cognitive domains of episodic memory, executive function, attention, working memory, calculation, and visuospatial function. Cognitive training will be conducted using a tablet-based application. Participants will be advised to eat something according to the recommendation of the Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet. They will be educated about vascular risk factor management every 2 weeks. The purpose of the motivational enhancement program is to induce, maintain, and strengthen motivation, which is a psychological resource to help maintain dementia prevention activities. All intervention will be administered via tablet personal computer (PC) application at home.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
100
For 24 weeks, participants will receive cognitive training twice a week, exercise 3 times a week, nutrition education 12 times, and education about vascular risk factor management every 2 weeks using the tablet PC application.
Chonnam National University Hospital
Gwangju, South Korea
NOT_YET_RECRUITINGInha University Hospital
Incheon, South Korea
RECRUITINGEwha Womans Seoul Hospital
Seoul, South Korea
NOT_YET_RECRUITINGChange of cognition
Repeatable Battery for the Assessment of Neuropsychological Status
Time frame: Change from Baseline at 24 weeks
Change of global cognition
Mini-Mental State Examination (range 0-30). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of function
Clinical Dementia Rating scale-Sum of Boxes (range 0-18). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of subjective memory
Prospective and Retrospective Memory Questionnaire (range 16-80). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of depression
Geriatric Depression Scale-15 items (range 0-15). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Quality of life assessed by the Quality of life-Alzheimer's disease
Quality of life-Alzheimer's disease (range 0-52). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of activities of daily living
Bayer Activities of Daily Living (range 1-10). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of nutritional behavior
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Ajou University Hospital
Suwon, South Korea
Nutrition Quotient for elderly (range 0-100). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of nutrition
Mini Nutritional Assessment (range 0-14). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of motor function
Short Physical Performance Battery (range 0-12). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Sleep quality assessed by the Pittsburgh Sleep Quality Index
Pittsburgh Sleep Quality Index (range 0-21). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of motivation
Self Determination Index (SDI) (range -66\~66). Higher scores of SDI indicate better performance.
Time frame: Change from Baseline at 24 weeks. Higher scores indicate better performance.