COntinue the SaMe Systemic Therapy After Local Ablative Therapy for Oligo Progression in Metastatic Breast Cancer - the COSMO Study

Inclusion Criteria: * Histologically confirmed invasive breast cancer * Metastatic breast cancer * Oligoprogression defined as one or two distant metastatic lesions, limited to one organ, or the primary tumor or locoregional lymph nodes, increasing ≥20% in size and be larger than 15 mm or if metabolic activity increases (with 20% in SUVmax) on FDG-PET-CT. * Systemic treatment can be either endocrine, targeted, chemotherapy or immune-checkpoint blockade * Patients should be on systemic therapy for at least six months. Status should be stable disease or partial or complete response for at least 6 months. * Oligoprogression has to be detected with radiological imaging comparing the lesion on the same type of imaging modality as has been used at the start of systemic therapy. * The radiological imaging that shows progression must be performed within 70days prior to LAT. * Bone metastases are classified as progressive if the lytic component of the lesion increases by ≥20% or the FDG-uptake increases by ≥20% on FDG-PET-CT * Oligo-progression has to be confirmed with a FDG-PET-CT-scan 5-7 weeks after the initial scan that showed oligoprogression. * Lesion(s) must be amenable to resection, radiotherapy or radiofrequency ablation with the intent of local obliteration * Age ≥18 * World Health Organization (WHO) Performance Status 0 or 1 * Signed written informed consent before patient registration according to ICH/GCP, and national/local regulations Exclusion Criteria: * Having received more than two lines of systemic therapy for MBC If a treatment regimen has been de-escalated without adding other therapies, this is seen as one line of therapy. For example: Pertuzumab/trastuzumab+docetaxel followed by pertuzumab/trastuzumab will be viewed as one line of systemic therapy. * Other malignancy except carcinoma in situ and basal-cell and squamous cell carcinoma of the skin, unless the other malignancy was treated ≥5 years ago with curative intent without the use of chemotherapy or radiation therapy * Current pregnancy or breastfeeding. Women of childbearing potential must use adequate contraceptive protection * Presence of any medical condition that would place the patient at unusual risk, up to the discretion of the clinician * Presence of any psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule