The purpose of this study is to assess the drug absorption of oral antibiotics in patients with short bowel syndrome.
When required, due to an infection, patients with short bowel syndrome will be treated with an intravenous antibiotic. The pharmacokinetic profile of that intravenous antibiotic will be determined. Once the full treatment with the intravenous antibiotic is over, the patient will be orally administered the same antibiotic, with determination of the oral pharmacokinetic profile, and both profiles will be compared, assessing the bioavailability of the oral antibiotic.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Each patient will receive the proper antibiotic to treat the infection, first intravenously, then orally
Each patient will receive the proper antibiotic to treat the infection, first intravenously, then orally
Each patient will receive the proper antibiotic to treat the infection, first intravenously, then orally
CHRU Nancy
Vandœuvre-lès-Nancy, Lorraine, France
RECRUITINGAssess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time -0.5 hours
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +0.5 hours
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +1 hour
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +1.5 hour
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +2 hours
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +4 hours
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +6 hours
Assess the bioavailability of the oral antibiotic in patient with short bowel syndrome
F (%)=(ASC PO)/(ASC IV) x (Dose IV)/(Dose PO)
Time frame: Time +8 hours
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Each patient will receive the proper antibiotic to treat the infection, first intravenously, then orally
Describe antibiotic absorption after oral administration in these patients
Peak plasma concentration (Cmax) after oral intake
Time frame: Time -0.5hour ; Time +0.5hour ; Time +1 hour ; Time+1.5 hour ; Time +2 hours ; Time+4 hours ; Time +6 hours ; Time + 8 hours
Describe antibiotic absorption after oral administration in these patients
Peak plasma concentration time after oral intake (Tmax)
Time frame: Time -0.5hour ; Time +0.5hour ; Time +1 hour ; Time+1.5 hour ; Time +2 hours ; Time+4 hours ; Time +6 hours ; Time + 8 hours
Describe antibiotic absorption after oral administration in these patients
Area under the plasma concentration versus time curve (AUC)
Time frame: Time -0.5hour ; Time +0.5hour ; Time +1 hour ; Time+1.5 hour ; Time +2 hours ; Time+4 hours ; Time +6 hours ; Time + 8 hours
Assess link between length of remaining bowel and antibiotic absorption
Length of remaining bowel (cm)
Time frame: At inclusion