The purpose of this study is to determine the mechanistic effects of an ionic calcium supplement in adults with atrial fibrillation, osteoarthritis, and hypertension. The study aims to determine if ionic calcium supplementation affects quality of life, rate of biological aging, bone densitometry, and blood biomarkers of bone metabolism over a six month period compared to non-ionic calcium comparator supplement.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Ionic calcium (IC), a calcium in a free ionic state (i.e., non-protein bound), is purported to improve calcium uptake and homeostasis leading to improved cellular signaling that may have been disrupted through environmental and lifestyle stressors.
Calcium carbonate supplementation in a solution identical in appearance, consistency, and taste to the intervention supplement.
Helfgott Research Institute
Portland, Oregon, United States
Rate of Biological Aging
Dunedin Pace of Aging Calculated objective measure of the rate of epigenetic aging
Time frame: Baseline
Rate of Biological Aging
Dunedin Pace of Aging Calculated objective measure of the rate of epigenetic aging
Time frame: Week 12
Rate of Biological Aging
Dunedin Pace of Aging Calculated objective measure of the rate of epigenetic aging
Time frame: Week 24
Patient Reported Outcomes Measurement Information system-29 Physical Function Sub-domain
Quality of Life
Time frame: Baseline
Patient Reported Outcomes Measurement Information system-29 Physical Function Sub-domain
Quality of Life
Time frame: Week 2
Patient Reported Outcomes Measurement Information system-29 Physical Function Sub-domain
Quality of Life
Time frame: Week 6
Patient Reported Outcomes Measurement Information system-29 Physical Function Sub-domain
Quality of Life
Time frame: Week 12
Patient Reported Outcomes Measurement Information system-29 Physical Function Sub-domain
Quality of Life
Time frame: Week 24
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Changes in Systolic and Diastolic Blood Pressure
Objective measure of blood pressure
Time frame: Baseline
Changes in Systolic and Diastolic Blood Pressure
Objective measure of blood pressure
Time frame: Week 2
Changes in Systolic and Diastolic Blood Pressure
Objective measure of blood pressure
Time frame: Week 6
Changes in Systolic and Diastolic Blood Pressure
Objective measure of blood pressure
Time frame: Week 12
Changes in Systolic and Diastolic Blood Pressure
Objective measure of blood pressure
Time frame: Week 24
Changes in Cognition
MoCA Assessment Score
Time frame: Baseline
Changes in Cognition
MoCA Assessment Score
Time frame: Week 6
Changes in Cognition
MoCA Assessment Score
Time frame: Week 12
Changes in Cognition
MoCA Assessment Score
Time frame: Week 24
Changes in Mood
Patient Health Questionnaire-9 Score
Time frame: Baseline
Changes in Mood
Patient Health Questionnaire-9 Score
Time frame: Week 2
Changes in Mood
Patient Health Questionnaire-9 Score
Time frame: Week 6
Changes in Mood
Patient Health Questionnaire-9 Score
Time frame: Week 12
Changes in Mood
Patient Health Questionnaire-9 Score
Time frame: Week 24
Changes in Anxiety
Generalized Anxiety Disorder-7 Score
Time frame: Baseline
Changes in Anxiety
Generalized Anxiety Disorder-7 Score
Time frame: Week 2
Changes in Anxiety
Generalized Anxiety Disorder-7 Score
Time frame: Week 6
Changes in Anxiety
Generalized Anxiety Disorder-7 Score
Time frame: Week 12
Changes in Anxiety
Generalized Anxiety Disorder-7 Score
Time frame: Week 24
Changes in Pain and Disability
Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score
Time frame: Baseline
Changes in Pain and Disability
Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score
Time frame: Week 2
Changes in Pain and Disability
Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score
Time frame: Week 6
Changes in Pain and Disability
Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score
Time frame: Week 12
Changes in Pain and Disability
Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score
Time frame: Week 24