Quantification and Repeatability of Magnetic Stimulation

N/AActive Not RecruitingNCT05302752

Swiss Federal Institute of Technology16 enrolled

Overview

In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Magnetic phrenic nerve stimulationOTHER

The intervention consists of bilateral rapid magnetic phrenic nerve stimulation on the neck using different stimulation intensities. On one visit, the effect of increasing chest wall stiffness and respiratory muscle work by adding incrementally small weights to the chest/abdomen will be investigated.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy * non-smoking * normal lung function * body mass index: 18.5-29.9 kg/m2 * able to communicate in english * willing to adhere to study rules Exclusion Criteria: * acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep * any metal or electronics inside of the body * presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators * history of seizures or epilepsy * tatoos on the stimulation sites * previous enrolment in this study * for women: pregnancy, breastfeeding, or intention to become pregnant during the study

Locations (1)

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Diaphragm contractility

Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters.

Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec

Data from ClinicalTrials.gov

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