Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and heat evoked brain signaling using a quantitative sensory testing device. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
80
Application of LIFU to induce temporary neuromodulation, effects tested with resting state and heat evoked (QST) fMRI signals
Fralin Biomedical Research Institute
Roanoke, Virginia, United States
RECRUITINGfMRI BOLD Signals
Changes in fMRI BOLD signal
Time frame: Participant study duration, approximately 3 weeks.
Changes in self-reported perceived pain
Change in subject perceived pain rating report on a numerical rating scale (0-10, 0 no pain, 10 worst pain)
Time frame: Participant study duration, approximately 3 weeks.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.