Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial remodeling; how it manifests in vivo and its underlying cellular and extracellular changes. The RELAX study will offer insight into myocardial remodeling, by comprehensively assessing function and structure of failing human hearts, and investigate its underlying cellular and extracellular changes.
Study Type
OBSERVATIONAL
Enrollment
200
Oslo University Hospital
Oslo, Oslo, Norway
RECRUITINGMRI functional parameters including Left Ventricular Ejection Fraction and Global Longitudinal Strain
Measurement of myocardial function by in-vivo methods. In-vivo myocardial function will be obtained by MRI and echocardiography. Measurements include LVEF and GLS.
Time frame: 1 years
MRI morphological parameters including LVEDV and LVESV.
Measurement of myocardial morphology by in-vivo methods including MRI and ultrasound. The expected outcome in regards to morphology is varying degrees of geometrical abnormalities.
Time frame: 1 years
Myocardial stiffness measured by MRI and ex-vivo methods.
Measurement of myocardial stiffness by in-vivo and ex-vivo methods. In-vivo myocardial stiffness will be measured by MRI. The expected outcome is varying degrees of stiffness in accordance with the underlying pathology as well as regionally in the heart. Ex-vivo methods include stiffness measurements by histology and protein analysis.
Time frame: 1 year
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