Assessing the Immunogenicity and Safety of a HIPRA's Candidate Booster Vaccination in Adults Fully Vaccinated With Adenovirus Vaccine Against COVID-19.

Inclusion Criteria: Subjects must meet all the following criteria to be considered eligible for the study: 1. Male or female, ≥ 18 years old at Day 0. 2. Participant must provide consent indicating that she or he understands the purpose and potential risks and is willing and able to participate in the study and comply with all the study requirements and procedures (scheduled visits, laboratory tests, complete diaries, etc). 3. Participant who has been vaccinated with two doses of Vaxzevria at least 91 days before Day 0 and a maximum of 365 days of the second dose. 4. Has a negative Rapid Antigen Test (RAT) at Day 0 5. Participants may have underlying illnesses if are stable and well-controlled according to the investigator judgment. A stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during the 3 months prior to screening and for which neither a significant change in treatment or hospitalization for worsening is expected in the near future. 6. Participant agrees not to donate blood, blood products and bone marrow at least 12 weeks before and after vaccination. 7. Contraceptive use should be consistent with local regulation for participants in clinical trials. 1. Female participants of childbearing potential \[defined as any female who has experienced menarche and until becoming postmenopausal\* (defined as having ≥ 12 months amenorrhea prior to screening without an alternative cause) unless is surgically sterile\]: i. Have a negative pregnancy test on the day of vaccination. ii. Use of any acceptable contraceptive method that should be started at screening and until 8 weeks after vaccination except hormonal contraception. Acceptable contraceptive methods are: 1\. Hormonal contraception (progestogen-only or combined): oral, injectable or transdermal (patch) at least 30 days before Day 0 and until 8 weeks after vaccination. 2\. Intrauterine device. 3. Vasectomized partner (the vasectomized partner should be the sole partner for that participant). 4\. Sexual abstinence \*\*, as a form of contraception, is acceptable if in line with the participant's lifestyle. 5\. Condom b. Male participants: i. Vasectomized participants. ii. Refrain from donating sperm for at least 28 days after day 0. iii. Agree to use a male condom may be considered in women of childbearing potential partners, from screening and for at least 28 days after day 0. iv. Sexual abstinence\*\*, as a form of contraception, is acceptable if in line with the participant's lifestyle. \* A high follicle stimulating hormone (FSH) level in the postmenopausal range may be used to confirm a post-menopausal state in women not using hormonal contraception or hormonal replacement therapy. \*\* Sexual abstinence is considered an effective method only if defined as refraining from heterosexual intercourse from screening until 8 weeks after receiving the vaccine for female participants and from screening until 4 weeks for male participants. Periodic abstinence (e.g., calendar, ovulation) and withdrawal are not acceptable methods of contraception. Exclusion Criteria: Participants meeting any of the following criteria will be excluded from the study: 8\. History of anaphylactic shock of any kind. 9\. History of COVID-19 infection. 10\. Participant received or plans to receive: 1. Live attenuated vaccines (licensed) within 4 weeks before or after receiving any study vaccine. 2. Other not live vaccines (licensed) within 14 days before and after receiving any study vaccine. 11\. Pregnancy or breast-feeding at screening or Day 0 (vaccination time-point) or willingness/intention to become pregnant during the study. Medical conditions: 12\. Participant has a clinically significant acute illness (this does not include minor self-limited illness such as mild diarrhoea) or fever (temperature ≥38º C (100.4ºF) at screening or within 48 hours prior to the planned vaccination (Day 0). 13\. Participant had a surgery requiring hospitalization (defined as inpatient stay for \> 24 hours) before vaccination and he/she has not received the hospital discharge at day 0; or has a surgery requiring hospitalization planned within 12 weeks after study vaccine administration. Minor surgical procedures not requiring hospitalization are accepted. 14\. Participant has any active malignancy even if under treatment except for (at the discretion of the investigator): a. Non-melanoma adequately treated skin cancer without evidence of disease. b. Adequately treated uterine cervical carcinoma in situ without evidence of disease. c. Adequately treated anal carcinoma in situ without evidence of disease. d. Localized prostate cancer. 15\. Participant has ongoing severe and non-stable psychiatric condition likely to affect participation in the study (e.g., ongoing and non-stable severe depression, recent suicidal ideation, severe eating disorder, psychosis). 16\. Participant has a problematic or risk use of substances including alcohol (except tobacco) that can compromise the study follow-up. Problematic or risk use of psychoactive substances is understood as the one that causes evident damage, whether it is dependence or any other physical, psychological, or social problem or that carries a high risk of suffering these damages. The negative consequences that consumption causes to third parties could be included. 17\. Participant has a bleeding disorder (e.g., factor deficiency, platelet disorder), blood dyscrasia, or continuous use of anticoagulants or has any condition that in the opinion of the investigator contraindicates intramuscular injections or frequent phlebotomy. The use of ≤ 325mg of aspirin or ≤ 75mg of clopidogrel per day as prophylaxis is permitted but not combined. 18\. Participant has abnormal function of the immune system as in autoimmune diseases, asplenia, recurrent infections or congenital/acquired immunodeficiency. Participants under immune-modifying treatment for any cause. Permitted: participants with stable clinical conditions (e.g., autoimmune thyroiditis, celiac disease, type 1- diabetes) and participants living with HIV with CD4 T cell count ≥ 400 cells/mm3 under stable antiretroviral treatment with a fully suppressed viral load ≥ 1 year are permitted \[one or two non-consecutives blips (HIV viral load ≤ 500 viral copies)\]. 19\. Participants have clinically significant and unstable cardiovascular, respiratory, hepatic, neurological, gastrointestinal, renal, or any other medical disorder as judged by the investigator and defined as disease requiring hospitalization or addition of new treatments or major dose adjustments within 3 months before screening. 20\. Chronic or recurrent administration (during at least 14 days) of systemic immunosuppressant medication (defined as given by oral or parenteral routes) within 12 weeks preceding the planned administration of study vaccine (Day 0). The use of an oral prednisone dose \<10mg per day or equivalent, ocular, topical, inhaled and nasal corticoids are allowed. 21\. Subject has received immunoglobulins and/or blood-derived products 12 weeks prior vaccination (Day 0) or expects to receive them during the study. 22\. Participant received any immunotherapy (monoclonal antibodies, plasma) aimed to prevent or treat COVID-19 within 90 days preceding the planned administration of study vaccine. Monoclonal antibodies for other indications are allowed. 23\. Participation in any research involving an investigational product (drug, biologic, device) within 12 weeks prior to vaccination and during the study. 24\. Participant has donated ≥ 450ml of blood products within 12 weeks before screening. 25\. Participant has any medical condition and/or finding that in the investigator opinion might increase participant risks, interfere with the study or impair interpretation of study data.