The purpose of the study is to understand the effect of Nicotinamide mononucleotide (NMN) on patients with polycystic ovary syndrome.
This study aims to evaluate the effects of NMN on reproductive endocrine and metabolism, chronic inflammation, and reproductive outcomes in women with polycystic ovary syndrome (PCOS), and to explore its underlying mechanisms to provide the intervention strategies for PCOS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
88
NMN capsules (total of 600mg/day) for 8 weeks
NMN-free placebo capsules for 8 weeks
Peking University Third Hospital
Beijing, China
Testosterone level
Changes of testosterone level in serum after intervention.
Time frame: From enrollment to the end of treatment at 8 weeks
Antral follicle counts
The number of antral follicle counts in each ovary will be determined using transvaginal ultrasonography for each participant.
Time frame: From enrollment to the end of treatment at 8 weeks
Menstrual cycle
The changes of menstrual cycle frequency after intervention.
Time frame: before and after 8 weeks of intervention
Luteinizing hormone (LH) level
Changes of LH level in serum after intervention.
Time frame: From enrollment to the end of treatment at 8 weeks
Follicle-stimulating hormone (FSH) level
Changes of FSH level in serum after intervention.
Time frame: From enrollment to the end of treatment at 8 weeks
Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) index
Changes in HOMA-IR index (fasting insulin \* fasting glucose/22.5) after intervention.
Time frame: From enrollment to the end of treatment at 8 weeks
Changes in other endocrine hormones
Time frame: From enrollment to the end of treatment at 8 weeks
Changes in blood NAD+ level and related metabolites
Time frame: From enrollment to the end of treatment at 8 weeks
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Multi-omics
Collect samples before and after 2, 4, 8 weeks of intervention
Time frame: From enrollment to the end of treatment at 8 weeks