It will be evaluate the safety of mesenchymal stem cells and adipose tissue derived stromal vascular fraction (SVF) in temporomandibular joint disease cases.
umbilical cord derived mesenchymal stem cells produced under GMP facility in Erciyes University and SVF produced in operation theatre.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
ATMP
Erciyes University
Kayseri, Turkey (Türkiye)
RECRUITINGChange from Baseline Pain at 15th day
using by Visual Analogue Scale (VAS); higher scores mean worse outcome
Time frame: 15th day
Change from baseline maximum mouth opening at 15th day
the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly
Time frame: 15th day
Change from baseline maximum mouth opening at 1 month
the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at first month; higher scores means a better outcome
Time frame: 1. month
Change from baseline maximum mouth opening at 3 months
the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at third month; higher scores means a better outcome
Time frame: 3. month
Change from baseline maximum mouth opening at 6 months
the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at 6th month,higher scores means a better outcome
Time frame: 6. month
Change from baseline pain at 1 month
using by Visual Analogue Scale (VAS)
Time frame: 1. month
Change from baseline pain at 3 month
using by Visual Analogue Scale (VAS)
Time frame: 3. month
Genkok center
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Change from baseline pain at 6 month
using by Visual Analogue Scale (VAS) higher scores mean worse outcome
Time frame: 6. month
Change from baseline 'comfort ' at 6th month
using by Visual Analogue Scale (VAS); higher scores mean better outcome
Time frame: 6 months