Gandouling in the Treatment of Wilson's Disease

Inclusion Criteria: * Comply with the diagnosis of Wilson's disease "Guidelines for Diagnosis and Treatment of Wilson's disease 2021" * The diagnosis of TCM syndromes complies with the syndrome of phlegm and blood stasis; Other copper-removing drugs * Patients who have been treated with complexing agents for copper-removing treatment can enter the study after a 2-week washout period * Age ≥15 years * Informed consent of patients or legal representatives, And sign the informed consent form. Exclusion Criteria: * Severe cerebral WD patients: obvious torsion spasm, dysphagia, or bed rest and other severe neurological impairment will interfere with the safety of the subjects (UWDRS Part I neurological function score ≥156 points) * Severe liver Type WD patients: Decompensated liver cirrhosis or liver cancer, manifested as portal hypertension, ascites, splenomegaly (WBC\<3.0\*109/L, PLT\<50\*1012/L), esophageal varices, gastrointestinal bleeding, Moderate to severe anemia or hepatic encephalopathy; severe liver fibrosis shown by imaging or any laboratory abnormality (UWDRS liver function score ≥ 17 points) * Moderate to severe depression, recent suicidal thoughts or behavior, Severe psychiatric symptoms (UWDRS Part III Psychiatric Symptom Score ≥ 54 points) * History of epileptic seizures within 6 months * Complicated with serious diseases such as brain tumors, brain trauma, blood diseases, Cardiogenic diseases, HIV, etc. * Nephritis, nephrotic syndrome, or kidney disease stage 3 or more * Pregnant, planned pregnancy or breastfeeding women * Cognitive dysfunction MMSE≤26 points * Those who are currently participating in other clinical trials * Cannot comply with the follow-up plan