Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin

Inclusion Criteria: * Written informed consent * Healthy male or female subjects aged \>=18 and \<=55 years * Body mass index \>=18.0 and \<32 kg/m2 Exclusion Criteria: * Abnormal ECG and/or prolonged QT interval * Subjects using nicotine products within 3 months prior to screening * Subjects who have lost or donated \>450 mL of whole blood or blood products within 30 days prior to the Screening Visit. * Use of any prescription medication within 14 days prior to the first dose of study medication, or any over-the-counter products (including natural health products, e.g., food supplements, vitamins, herbal supplements) within 7 days prior to the first dose of study medication, except for topical products without significant systemic absorption. * Use of any drugs or substances known to induce or inhibit hepatic drug metabolism within 28 days prior to administration of the study medication * Consumption of grapefruit or grapefruit juice, pomelo or star fruit within 7 days of first dose of study drug on Day 1 * Use of hormonal contraception or hormone replacement therapy within 14 days prior to first dose of study drug. * No COVID-19 vaccines are allowed within 28 days prior to first dose of study drug. * History of or current alcohol abuse or drug addiction * Subjects who are pregnant or breast feeding * Subjects who have received any investigational drug within 30 days or 5 half-lives of the drug (whichever is longer) prior to screening. * Subjects who have any significant health issues as deemed by their treating physician/investigator