Oxytocin and Sleeve Gastrectomy

Centre Hospitalier Universitaire de Nice20 enrolled

Overview

Morbid obesity has become a common condition and there is no effective drug that is able to induce a sustained weight loss. Currently bariatric surgery remains the only effective means that is able to lead to long term sustained weight loss. Oxytocin is a hormone secreted by the hypophysis that regulates negatively the adipogenesis and positively the osteogenesis. Oxytocin also regulates appetite and its role in weight loss in humans has not been investigated so far. The aim of the present study is to elucidate whether plasma levels of oxytocin and sleeve gastrectomy induced weight loss are correlated in pre-menopausal morbidly obese women.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Obesity, Morbid

Interventions

Sleeve GastreextomyOTHER

The aim of the present study is to elucidate whether serum levels of oxytocin and sleeve gastrectomy induced weight loss are correlated in pre-menopausal morbidly obese women.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women aged 18-65, pre-menopausal, * able to read and understand the written informed consent, * with a BMI \> 40 or 35 * with at least one obesity linked comorbidity among blood hypertension, * type 2 diabetes, * sleep apnea syndrome, * invalidating arthritis, * indication for sleeve gastrectomy * accepted by the multidisciplinary committee and the CPAM (local health care system agency), * affiliation to the Fre,nch health care system, * signature of the informed consent. Exclusion Criteria: * Post-menopausal women, * any other bariatric procedure that sleeve gastrectomy, history of any other bariatric procedure, * pregnancy, * age less than 18 years under, under guardianship * Patients undergoing any other procedure that the planned sleeve gastrectomy or undergoing a second bariatric procedure for a complications during the 6 months follow-up.

Locations (1)

CHU de Nice

Nice, Alpes-maritimes, France

Outcomes

Primary Outcomes

plasma leves of oxytocin

Correlation between plasma leves of oxytocin (pcgr/ml) and weight loss (BMI Kg/m2) 6 months after sleeve gastrectomy

Time frame: 6 months

Secondary Outcomes

sleeve gastrectomy

Correlation between weight 6 months after sleeve gastrectomy and fibrosis within adipose tissue

Time frame: 6 months

Data from ClinicalTrials.gov

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