Cytokine Expression in Psoriasis Patients with and Without Joint Involvement

Poitiers University Hospital40 enrolled

Overview

The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.

Psoriatic arthritis and Cutaneous Psoriasis are polygenic inflammatory disorders with high burden on the quality of life of patients. Pathophysiology of those disease remain incompletely understood. Recent publications seem to demonstrate an implication of IL-1 family cytokines in the pathogenesis of both diseases. In the literature, results are discordant and focus mainly on cytokines levels in serum of patients. Moreover, few studies compare psoriatic arthritis patients with cutaneous psoriasis patients. We propose here to study cytokines profiles of patients with those conditions in sera, after ex-vivo stimulation of peripheral blood mononuclear cells, and in skin biopsies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Psoriasis Psoriatic Arthritis

Interventions

Blood sample collectionOTHER

Blood sample collection

Skin sample collectionOTHER

Skin sample collection

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * For psoriasis patients : * Age over 18 years old * Signed informed consent * 5 year old psoriasis at least * At least one skin lesion over 2 cm * Without any articular symptoms * Without any DMARDs * Without anticoagulant treatments or coagulation disease * With normal articular and enthesis sonography * For psoriatic arthritis patients : * Age over 18 years old * Signed informed consent * Psoriatic arthritis according to CASPAR criteria * Without any DMARDs * Without anticoagulant treatments or coagulation disease * With at least one synovitis at inclusion * For controls * Age and sex matched with a patient without any rheumatic or dermatologic medical conditions * No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old Exclusion criteria: ▪ For psoriasis patients : * Joint damage according to CASPAR criteria * Echography activity in favor of chronic inflammatory rheumatism * For patients and controls: * Without social protection rights * People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.

Locations (1)

Chu Poitiers

Poitiers, France

RECRUITING

Outcomes

Primary Outcomes

Comparison of cytokine levels in sera, after culture of PBMC stimulated with LPS or CD3/CD28 agonist antibodies between the three groups

Time frame: At inclusion

Secondary Outcomes

Comparison of cytokine levels in skin biopsies between Psoriatic Arthritis and Cutaneous Psoriasis patients

Time frame: At inclusion

Correlation of cytokine levels with rheumatologic disease activity, or dermatologic disease activity

Time frame: At inclusion

Central Contacts

Guillaume LARID

CONTACT

+33549444465 rhumatologie@chu-poitiers.fr

Data from ClinicalTrials.gov

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