This study is to investigate retrospectively the results of cervical cytology and high-risk human papillomavirus in the past 20 years recorded in Peking Union Medical College Hospital. The histological findings after cervical cancer screening were reviewed. The diagnostic values of different screening strategies were compared based on the results of cervical histology. The primary endpoint is the diagnosis of grade 2 cervical intraepithelial neoplasia (CIN2) or more severe lesions (CIN2+). The secondary endpoints include following objectives: (1) the invasive procedures needed according to the screening results; (2) the diagnosis of vaginal and/or vulval intraepithelial neoplasia; (3) the persistence and recurrence of human papillomavirus infection; and (4) the cost-effectiveness of screening strategies for CIN2+.
Study Type
OBSERVATIONAL
Enrollment
10,000
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGCIN2+
CIN2+ detected by various screening methods
Time frame: One year
Invasive procedures
Invasive procedures needed according to the screening results
Time frame: One year
Vaginal intraepithelial neoplasia (VaIN)
VaIN detected by various screening methods
Time frame: One year
Vulval intraepithelial neoplasia (VIN)
VIN detected by various screening methods
Time frame: One year
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