The investigators will examine how a combination of pharmacological mineralocorticoid receptor (MR) stimulation and psychosocial stress will influence prosocial behavior in patients with Borderline Personality Disorder (BPD) compared to healthy controls (HC).
The investigators will examine whether MR stimulation enhances prosocial behavior in BPD patients under additional psychosocial stress. Participants will be randomly assigned to receive either fludrocortisone as an MR stimulant or placebo. Afterwards, participants will either undergo the stress or placebo condition of the Trier Social Stress Test ((P-)TSST). Subsequently, cognitive and emotional empathy, as well as sharing and punishment behavior will be measured.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
TRIPLE
Enrollment
240
pill of fludrocortisone
placebo pill
psychosocial stress induction
Charite University
Berlin, Germany
Empathy: Multifaceted Empathy Test
correct answers (mental state of the subject in the photos), rating of own emotional reaction
Time frame: 15 minutes after (P-)TSST
Sharing behavior
amount of monetary units (max 100) shared with co-player
Time frame: 10 minutes after (P-)TSST
Punishment behavior
number of rejected offers from co-player
Time frame: 10 minutes after (P-)TSST
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control condition