The Predictors of ICU Admission of oPRES

Dunjin Chen366 enrolled

Overview

The purpose of this study is to explore the predictors of ICU admission of obstetric posterior reversible encephalopathy syndrome.

The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the predictors of ICU admission during 2012 to 2021.Then, the investigators grouped all the patients into ICU group and Non-ICU group according to ICU admission or not.

Study Type

OBSERVATIONAL

Enrollment

366

Conditions

Posterior Reversible Encephalopathy Syndrome Intensive Care Units

Interventions

Whether the patient needs to be admitted to the ICUOTHER

According to ICU admission or not, patients were grouped into ICU group and NOT-ICU group.

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Pregnant Women were diagnosed of PRES. 2. all patients provided written informed consent Exclusion Criteria: 1. patients combined with other neurological disorders 2. patients combined with mental illness

Locations (1)

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, China

Outcomes

Primary Outcomes

Blood Pressure(BP)

blood pressure including systolic blood pressure (SBP), and diastolic blood pressure (DBP).

Time frame: The BP of patients was obtained immediately at the onset of symptoms.

severity of the edema

The extent and severity of the edema observed in the lesion area were graded on a scale of 0-5 by evaluating FLAIR images.(0, normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema \> cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema \> cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost com- pletely conﬂuent; 5, involved regions are fully conﬂuent and con- tinuous, ventricular deformity due to the oedema).

Time frame: Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment.

pregnancy outcomes

The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients.

Time frame: The pregnancy outcomes will record immediately when the patients deliver.

biochemical parameters

The level of lactate dehydrogenase(LDH) will be measured，and LDH﹥380U/L means a worse outcome.

Time frame: Biochemical indicators were collected within 1 week of the hospital stay.

Data from ClinicalTrials.gov

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