Long Term Prospective Study of Tai Chi Intervention to Prevent MCI From Conversion to Dementia

Inclusion Criteria 1. Male and female participants aged 55 to 85 years (inclusive) at the time of screening 2. Willing and able to give informed consent by GCP and local guidance. 3. Meets the National Institute on Aging of the National Institutes of Health and Alzheimer's Association (NIA-AA) diagnostic criteria for "Mild Cognitive Impairment Due to Alzheimer's Disease" (2011); does not meet the American Psychiatric Association's diagnostic criteria Diagnostic and Statistical Manual of Mental Disorders, Revised IV (DSM-IV-R) diagnostic criteria for dementia; 4. Main complaint of memory loss, 24≤MMSE and/or 17≤MOCA\<26 points, with one or more cognitive domains impairments; 5. CDR global score of 0.5, with memory box score ≥0.5 6. Functional activities questionnaire (FAQ) \<5 7. Hachinski ischemia score ≤4; 8. Have the physical, cognitive, listening, speech, literacy and language skills necessary to participate in all tests; 9. Capable of performing MR 10. Allowed and Prohibited concomitant and treatments. During the clinical study, the following drugs are prohibited: Acetylcholinesterase inhibitors, N-methyl-D-aspartate (NMDA) antagonists (eg, memantine, amantadine, ketamine, and dextromethorphan), adrenal corticosteroids, central nervous system stimulants, traditional Chinese medicine and various medicines that can improve memory or cognition; During the clinical study, the following drugs cannot be added: Antipsychotics, antidepressants, sedative-hypnotics for sleep (zopiclone, alprazolam, estazolam can be used temporarily if necessary) For long-term use of the above drugs, the dose should be kept as stable as possible during the study. Exclusion Criteria 1. Cognitive impairment caused by other reasons (for example) cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, trauma, other physical and chemical factors (drugs, alcohol, CO, etc.), important physical diseases (hepatic encephalopathy, pulmonary encephalopathy, etc.), brain tumor, endocrine diseases (thyroid disease, parathyroid disease), and vitamin deficiency or any other cause of dementia; 2. Abnormal folate, thyroid, and/or vitamin B12 values that cannot be corrected before baseline visit. 3. Major structural brain disease as judged by central MRI Diagnostic Imaging Review Team (eg, ischemic infarcts, subdural hematoma, hemorrhage, hydrocephalus, brain tumors, multiple subcortical ischemic lesions. or a single lesion in a critical region \[eg, thalamus\]). Mild white matter changes without clinical significance and no more than 2 lacunar infarcts are permitted. 4. Mental illness determined by Diagnostic and Statistical Manual of Mental Disorders (DSM) V criteria, that is unstable within 12 months, or would interfere with study assessments, including schizophrenia or other psychotic disorders, bipolar disorder, severe depression, or delirium. 5. DSM V diagnosis of alcohol or other substance abuse dependence within the last 12 months. 6. History or current diagnosis of significant cardiac arrhythmias, myocardial infarction, transient ischemic attack, or cerebrovascular accident, uncompensated congestive heart failure New York Heart Association class III and IV. 7. Major medical illness or unstable medical condition within 6 months of screening that in the opinion of the investigator may interfere with the participant's ability to comply with study procedures and abide by study restrictions, or with the ability to interpret safety data, including any physical disability (eg. blindness. deafness, non-cognitive related speech impairment, sensory or motor dysfunction) that would prevent completion of study procedures or assessments. 8. Cancer except: 1. History of any cancer that has been in remission (no evidence of recurrence) for \> 3 years from the screening 2. Participants with basal cell or stage I squamous cell carcinoma of the skin, stable untreated cancer as prostate or meningioma. 9. Exercise regularly within 6 months prior to screening. 10. Participants are excluded if they 1. have participated in any other clinical study within 4 weeks prior to screening visit 2. have participated in another Tai chi clinical study at any time 3. plan to take part in another clinical study during this study. 11. Geriatric Depression Scale-15(GDS-15) total score \> 7 at screening 12. The researcher estimates that the subject's compliance is poor, and it is believed that the subject is unlikely to complete the study.