Direct Application of Integra Bilayer Matrices on Bare Calvarium Without Preliminary Burring

Inclusion Criteria: Any full-thickness scalp wound extending to the cranium, devoid of pericranium that is: 1. greater than or equal to 2 cm and/or is deemed by the treating physician not to be amenable to closure by simple means, primary closure or local flap. 2. occurring in as elder patient \> 55 years old with co-morbid conditions that constitute and anesthetic risk (ASA) \>=3 that demonstrates punctate bleeding from healthy appearing cortical bone following debridement/extirpation Exclusion Criteria: 1. hypersensitivity of bovine collagen and/or chondroitin 2. previous treatment under same protocol 3. current or planned treatment/medication know to interfere with the rate and quality of wound healing. 4. suspected signs of wound infection 5. suspected/known diagnosis of osteomyelitis, osteoradionecrosis, or non-availability of cortical bone 6. anticipated defect following debridement or tumor extirpation extending past the outer cortical layer or cranium 7. history of radiation to the field 8. history of other conditions/illness compromising the wound healing process (ESRD, immunosuppression), 9. absence of punctate cortical bleeding 10. prior surgeries that would be expected to impair wound healing or vascularity of the underlying bone(e.g. history of craniectomy/bone flap, history of scalp flap/VP shunt.