The Efect of Azithromicyn on Bronchopulmonary Displasia in Extremely Preterm and Very Preterm Infant

Universitas Indonesia120 enrolled

Overview

This study was to see the effectiveness of azithromycin in preventing the incidence of bronchopulmonary dysphasia in extremely preterm and very premature infants. Inclusion criteria were infants with a gestational age of 25-31 weeks 6 days who experienced respiratory distress and their families had agreed to participate in the study, then randomized. The intervention was in the form of giving azithromycin in the intervention group and no intervention was carried out in the control group and then followed up to 36 weeks PMA

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

120

Conditions

Bronchopulmonary Dysplasia Intraventricular Hemorrhage Necrotizing Enterocolitis

Interventions

Outcomes

Primary Outcomes

Bronchopulmonaty Dysplasia

Use of oxygen suplemantation at least 28 days until 36 weeks PMA

Time frame: BPD mild room air until 36 weeks PMA, BPD moderate use of oxygen <30% until 36 weeks PMA, BPD severe use of oxygen >30% until 36 weeks PMA

Secondary Outcomes

Intraventricular hemorrhage

Sign of IVH from head ultrasonography from USG we can found the sign of IVH grade 1 if we perform head USG and we found bleeding in germinal matriks grade 2 if we perform head USG and we found bleeding intaventricular without ventricle dilatation grade 3 if we perform head USG we found bleeding intraventrucular with dilatation of ventricle grade 4 if we perform head USG and we found bleeding in parenchime Head USG perform at 1-7 days and then in 6 weeks

Time frame: 1 days-7 days, and 6 weeks

Necrotizing Enterocolitis

Sign and symptoms of NEC from clinical, laboratory, and radiology If we found : From clinical sign : temperature \< 36.5 degree C or \> 37.5 degree C, Respiratory rate \> 60/min with retraction, abdominal distention Laboratory examination : trombocyte \< 100.000/mm3, natrium \<135 meq/L, pH \< 7.1, BE \> -12, CRP \> 5 IU Radiology examination : sign of pneumatosis intestinalis NEC : clinically + laboratory + radiology

Time frame: 1 days-36 weeks PMA