Integration of Cryobiopsies for ILD Diagnoses- Experience Based on 250 Biopsy Procedures.

Aarhus University Hospital250 enrolled

Overview

A retrospective study on safety and Diagnostic yield in using cryobiopsies as a Diagnostic tool in diagnosing patients under investigation for Interstitial lung diseases. This includes a registration of procedural techniques, complications ( pneumthorax, hemorrhage, exacerbation and mortalt), days admitted at the hospital, diagnoses and diagnostic yield.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Interstitial Lung Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>18years of age * suspected of Interstitial lung Disease * cryobiopsies performed. Exclusion Criteria: * FVC below 50% of predicted * DLCO below 35% * Body Mass Index (BMI) above 35 * pulmonary hypertension with a tricuspidal gradient above 40 mmHg * other cardiac or other comorbidities that would increase the risk of complications

Outcomes

Primary Outcomes

Pneumothorax

Pneumothorax, hemorrhage, acute exacerbation and death

Time frame: 2 weeks

Hemorrhage

Hemorrhage during the procedure

Time frame: 3 days

Acute exacerbation

Acute exacerbation after the procedure

Time frame: 100 days

Mortality

Mortality after the procedure

Time frame: 100 days

Secondary Outcomes

Diagnostic yield

Diagnostic yield is discussed at multidisciplinary team meetings i.e, adequate biopsies (\>50% alveolated biopsies), histologic pattern, kontribution to the diagnosis.

Time frame: 1 month

Data from ClinicalTrials.gov

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