Evaluation of New Biomarkers in Stage 3 and 4 Endometriosis

Bagcilar Training and Research Hospital79 enrolled

Overview

The diagnostic value of Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and Proinflammatory cytokines (TNF-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in organ-specific involvement, their relationship with symptoms, and the changes of these markers in the postoperative period will be evaluated.

Serum Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and proinflammatory cytokines (TNF-a and interleukin-6) values were studied by taking blood samples from all patients before and three months after the operation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endometriosis

Interventions

endometriosis surgeryPROCEDURE

Laparoscopy was performed in the follicular phase of the woman's menstrual cycle and all recognizable endometriotic lesions were treated by bipolar coagulation, resection of endometriotic nodules and ovarian cystectomy.

other benign condition surgeriesPROCEDURE

ovarian cystectomy, bilateral tubal ligation, myomectomy etc.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Stage III and IV endometriosis patients requiring surgery due to chronic pelvic pain or suspected malignancy Exclusion Criteria: 1. Malignant disease 2. Ovarian failure 3. Acute pelvic inflammatory disease 4. Smokers 5. Pregnancy 6. Chronic autoimmune disease

Locations (1)

Bagcilar Teaching and Research Hospital

Istanbul, Bagcilar, Turkey (Türkiye)

Outcomes

Primary Outcomes

Diagnostic value of serum Annexin V in endometriosis

To determine whether serum Annexin V levels (ng/mL) can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Diagnostic value of serum sVCAM-1 in endometriosis

To determine whether serum sVCAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Diagnostic value of serum sICAM-1 in endometriosis

To determine whether serum sICAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Diagnostic value of serum Vascular Endothelial Growth Factor in endometriosis

To determine whether serum Vascular Endothelial Growth Factor (pg/mL) levels can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Diagnostic value of serum TNF-alpha in endometriosis

To determine whether serum TNF-alpha (pg/mL) levels can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Diagnostic value of serum Interleukin-6 in endometriosis

To determine whether serum Interleukin-6 (pg/mL) levels can be used as diagnostic markers of endometriosis disease.

Time frame: Up to 4 months

Data from ClinicalTrials.gov

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