The disruption of colonic microbiota has been linked to a number of diseases, mainly cardiovascular and kidney diseases. One possible means to improve the microbiota is to increase dietary fiber intake as the intake of dietary fiber shifts the fermentation from proteolytic saccharolytic fermentation. Beta-glucans are soluble dietary fibers mainly found in oats and barley. Results from previous studies suggest that the consumption of barley reduces the risk of cardiovascular and kidney diseases. Therefore, this study will explore the effect of barley beta-glucans on markers of Cardiovascular and Renal health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
25
Intervention will involve intake of 50% barley substituted wheat bread.
Khyber Medical University, Peshawar
Peshawar, KPK, Pakistan
Change in Serum Thiobarbituric acid reactive substances (TBARs) from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
Change in Serum Total antioxidant capacity (TAC) from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
Change in Serum Nitric oxide from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
change in Serum E-selectin from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
Change in Serum P-cresyl sulfate from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
Change in Serum Indoxyl sulfate from baseline to 4 weeks
Time frame: Baseline and after 4 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.