Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma

Inclusion Criteria: 1. Subjects must have histologically confirmed non-Hodgkin lymphoma relapsed after 2 or more lines of therapy or disease refractory to chemotherapy (defined as progressive disease or stable disease lasting ≤6 months, as best response to most recent chemotherapy regimen; or disease progression or recurrence ≤12 months after prior autologous stem cell transplantation (ASCT). 2. No evidence of central nervous system (CNS) lymphoma. 3. Male or female \> 18 years of age. 4. Eastern Cooperative Oncology Group Performance status ≤ 2. 5. At least one measurable lesion. 6. \>2 weeks since prior radiation therapy or systemic therapy at the time of leukapheresis. 7. Total bilirubin ≤ 1.5 mg/dL (except in patients with Gilbert's syndrome). 8. Aspartate aminotransferase/alanine transferase ≤ 2.5 X institutional upper limit of normal. 9. Serum creatinine \< 1.5 mg/dL. 10. Cardiac ejection fraction of \>50%, and no evidence of pericardial effusion, as determined by an echocardiogram. 11. Adequate pulmonary function as defined as pulse oximetry ≥ 92% on room air. 12. Subjects (or legal guardians) must have the ability to understand and the willingness to sign a written informed consent document. 13. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a contraceptive method with a failure rate of \< 1% per year during the treatment period and for at least 90 days after the BAFF CAR-T cell infusion. 14. For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm. Exclusion Criteria: 1. ASCT within 6 weeks of informed consent. 2. History of allogeneic hematopoietic stem cell transplantation. 3. Active graft-versus-host disease. 4. Active central nervous system or meningeal involvement by lymphoma or leukemia. 5. Active malignancy, other than non-melanoma skin cancer or carcinoma in situ (e.g. cervix, bladder, breast). 6. Less than 28 days elapsed between prior treatment with investigational agent(s) and the day of lymphocyte collection. 7. New York Heart Association class IV congestive heart failure. 8. Cardiovascular disorders including unstable angina pectoris, clinically significant cardiac arrhythmias, myocardial infarction or stroke (including transient ischemic attack, or other ischemic event) within 6 months prior to registration. 9. Active infection requiring intravenous systemic treatment. 10. HIV seropositivity. 11. Pregnant or breastfeeding women. 12. Evidence of myelodysplasia or cytogenetic abnormality indicative of myelodysplasia on any bone marrow biopsy prior to initiation of therapy. 13. Serologic status reflecting active hepatitis B or C infection. 14. Patients with history of clinically relevant CNS pathology such as epilepsy, seizure disorders, paresis, aphasia, uncontrolled cerebrovascular disease, severe brain injuries, dementia and Parkinson's disease. 15. Subjects with uncontrolled intercurrent illness. 16. Known additional malignancies which require systemic treatment. 17. History of autoimmune disease with requirement of immunosuppressive medications (other than low dose steroids) within 6 months.