The purpose of the study is to establish a Standard Operating Procedure (SOP) for the screening of pathologies associated with prediabetes and type 2 diabetes.
The proposed study will enable screening of pathologies associated with cardiometabolic diseases (i.e., hypertension, prediabetes, insulin resistance, diabetes, and obesity). The Meal-Induced Insulinemia and Glycemia (MIG) score will correlate with those dysfunctions that are components of the Absence of Meal-Induced Insulinemia (AMIS) syndrome. Overall the study aims: 1. To establish an SOP for screening pathologies associated with cardiometabolic diseases using a combination of biometrics and metabolomics. 2. To compare a participant's MIG score and hepatalin levels following consumption of a standardized test meal containing macronutrients, and the measurement of several indices of organ health associated with diabetes (i.e., body composition, handgrip strength, spirometry, blood pressure, and heart rate variability). The study will involve 2 study visits: Visit 1 - Screening and Visit 2 - Intervention (Test meal administration and postprandial blood collection).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
15
During this study visit, a standardized test meal will be administered. Blood samples will be collected at baseline and then every 30 minutes for 2 hours after test meal.
SNI Clinical Research
Winnipeg, Manitoba, Canada
Establishment of proposed Wellness Transformation Network clinical trial procedures.
Practical feasibility of the proposed Wellness Transformation Network clinical trial procedures (Yes/No)
Time frame: 2 Weeks
Time course and curve analysis of serum glucose response after the test meal administration.
Time frame: Test: Baseline, every 30 minutes up to 2 hours after test meal administration
Time course and curve analysis of serum insulin response after the test meal administration.
Time frame: Test: Baseline, every 30 minutes up to 2 hours after test meal administration
Time course and curve analysis of serum triglycerides response after the test meal administration.
Time frame: Test: Baseline, every 30 minutes up to 2 hours after test meal administration
Time course and curve analysis of plasma hepatalin response after the test meal administration.
Time frame: Test: Baseline, every 30 minutes up to 2 hours after test meal administration
Time course and curve analysis of Meal Induced Glycemia (MIG) scores response after the test meal administration.
MIG is calculated using the formula: MIG = (post meal insulin mIU/L X post meal glucose mmol/L) minus (fasted insulin mIU/L X fasted glucose mmol/L). Higher score equates to a worse (unhealthy) outcome.
Time frame: Test: Baseline, every 30 minutes up to 2 hours after test meal administration
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