The primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (PK) of a single dose of ALXN1720 in participants with proteinuria.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
13
All enrolled participants will receive a single dose of ALXN1720 on Day 1 followed by a Post-treatment and Follow-up Period (92 days).
Clinical Trial Site 2
Anyang-si, Gyeonggi-do, South Korea
Clinical Trial Site 1
Seoul, South Korea
Serum Concentration of ALXN1720
Time frame: Day 1 (0.5 hours predose and postdose) and postdose on Days 2, 3, 8, 15, 29, 43, and 57
Number of Participants With Treatment-Emergent Adverse Events
Time frame: Day 1 (Predose) through Follow-up (Day 92)
Serum Concentration of Free and Total Complement Component 5 (C5)
Time frame: Day 1 (0.5 hours predose and postdose) and postdose on Days 2, 3, 8, 15, 29, 43, and 57
Number of Participants With Antidrug Antibodies (ADAs) to ALXN1720
Time frame: Day 1 (predose) through Day 57
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