Treatment With SGLT-2 Inhibitor for Postoperative Hyperglycemia in Acute Abdominal Surgery - a Randomized Trial

Zealand University Hospital24 enrolled

Overview

The aim of the study is to investigate the effect of an SGLT-2 inhibitor on postoperative hyperglycemia after acute abdominal surgery in patients without diabetes

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Hyperglycemia Stress Hyperglycemia

Interventions

SGLT2 inhibitorDRUG

10 days of SGLT2 inhibitor after surgery

PlaceboDRUG

10 days of placebo after surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \- Admitted to the ward after acute abdominal surgery (ASAP patient at Slagelse Hospital, OMEGA patient at Zealand University Hospital) * At least two independent measurements of blood glucose above 7.7mmol/l within the first 48 hours after surgery * Age of 18 to 85 * Must be able to understand and sign informed content Exclusion Criteria: * Patients diagnosed with diabetes mellitus * Impaired kidney function (eGFR \< 45mL/min) * Severe liver disease (defined as transaminases above X 3 normal levels) * Acute pancreatitis within the last two months or a history of chronic pancreatitis * Participation in another pharmacological intervention trial * Predictable poor compliance (for instance mentally impaired) * Pregnancy or lactation (fertile women must have a negative serum or urine pregnancy test to participate) * Allergy to study medication

Outcomes

Primary Outcomes

time in range

percentage of time in range defined as blood glucose between 3.9 and 7.8mmol/l. Blood glucose will be measures continuously while taking the study medication)