Anti-BCMA CAR T-Cell Therapy for R/R ITP

Inclusion Criteria: * Refractory ITP defined according to the recent consensual criteria ( 'Chinese guideline on the diagnosis and management of adult primary immune thrombocytopenia (version 2020)'), or relapse ITP defined as ITP patients who have responded to first-line therapy (glucocorticoids or immunoglobulins) and anti-CD20 monoclonal antibody, but cannot maintain the response. * Ages 18-65 years inclusive. * Adequate venous access for apheresis or venous blood and no other contraindications for leukocytosis. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * Subjects should have full capacity for civil conduct, understand necessary information，sign the informed consent form voluntarily，and have good corporation with the content of this research protocol. Exclusion Criteria: * Secondary ITP. * Patients with a known history or prior diagnosis of arterial thrombosis (such as cerebral thrombosis, myocardial infarction, etc.), or comorbidity of venous thrombosis (such as deep vein thrombosis, pulmonary embolism), or are using anticoagulant/antiplatelet drug at the beginning of trial. * Patients with a known history or prior diagnosis of serious cardiovascular disease. * Patients with uncontrolled infection, organ dysfunction or any uncontrolled active medical disorder that would preclude participation as outlined. * Patients with malignancy or history of malignancy. * Failed T cell expansion test. * During screening, hemoglobin \<100g/L; absolute value of neutrophil count \<1.5×10\^9/L. * During screening, serum creatinine concentration \> 1.5x the upper limit of the normal range, total bilirubin \> 1.5x the upper limit of the normal range, alanine aminotransferase and aspartate aminotransferase \> 3x the upper limit of the normal range, Left ventricular ejection fraction ≤ 50% by echocardiography, Pulmonary function ≥ grade 1 dyspnea (CTCAE v5.0), blood oxygen saturation\<91% without oxygen inhalation. * Prothrombin time (PT) or prothrombin time-international normalized ratio (PT-INR) or activated partial thromboplastin time (APTT) exceeding 20% of the normal reference range; or a history of coagulation abnormalities other than ITP. * Either HIV antibody or syphilis antibody is positive; hepatitis C antibody is positive and the detection of HCV-RNA exceeds the laboratory test upper reference limit; hepatitis B surface antigen is positive and the detection of HBV-DNA exceeds the laboratory test upper reference limit. * Participated in other clinical studies within 3 months before this CAR-T cell infusion. * Patients is pregnant or breastfeeding, or planning pregnancy. * Patients is fertile and the investigator determines the case is inappropriate to participate. * History of severe drug allergy or known allergy to CAR-T treatment related drugs. * Suspected or established alcohol, drug or drug abuse. * The investigator judges that it is not suitable to participate in this trial.