The Dampness Syndrome of Chinese Medicine Cohort Study

Guangzhou University of Traditional Chinese Medicine100,000 enrolled

Overview

The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.

DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.

Study Type

OBSERVATIONAL

Enrollment

100,000

Conditions

Chronic Disease Cancer Dementia Alzheimers

Eligibility

Sex: ALLMin age: 35 YearsMax age: 79 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Residents aged 30 to 79, whose residence is consistent with their registered permanent residence location; 2. Residents who voluntarily participate in the project, agree to the collection of their biological information, and sign the informed consent form; 3. Residents who have no mental illness and other related diseases, and display a normal ability of expression and understanding; Exclusion Criteria: 1. Residents who reject collaboration; 2. Residents who allow no follow-up visits.

Outcomes

Primary Outcomes

emerging diseases

This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments.

Time frame: through study completion, an average of 1 year

Secondary Outcomes

Montreal Cognitive Assessment(MoCA)

MoCA is a brief, 30-question test that helps healthcare professionals detect cognitive impairments very early on, allowing for faster diagnosis and patient care. MoCA is the most sensitive test available for detecting Alzheimer's disease, measuring executive functions and multiple cognitive domains. The value range 0-30: higher scores mean a better Cognitine. The score above 26 is considered the normal congnitive level

Time frame: through study completion, an average of 1 year

European Quality of Life 5-dimensional questionnaire (EQ-5D-5L)

The EQ-5D comprises five dimensions of health: mobility, ability to self-care, ability to undertake usual activities, pain and discomfort, and anxiety and depression. . EQ-5D-5L, includes five levels of severity for each dimension (no problems, slight problems, moderate problems, severe problems, and extreme problems). The value range 0-100: higher scores mean a worse outcome.

Time frame: through study completion, an average of 1 year

Mini-Mental State Exam (MMSE)

MMSE is a widely used test of cognitive function among the elderly; it includes tests of orientation, attention, memory, language and visual-spatial skills. The value range 0-30: higher scores mean a better Cognitine.

Time frame: through study completion, an average of 1 year

interview questionnaire

Demographic characteristic, life style. disease history, allergies will be involoved.

Time frame: through study completion, an average of 1 year

change of the blood routine results

WBC, RBC, PLT , HB, NEUT% and LYM% will be tested and recorded. Above or below each mormal value will be considered as abnormal.

Time frame: through study completion, an average of 1 year

urine routine

urinary WBC and urinary RBC will be observed. negative or below 5/HP is normal. BLO and GLU and PRO in urine will also be test. Negative is normal.

Time frame: through study completion, an average of 1 year

change of faeces routine

cells in faeces will be tested such as RBC and WBC. Negative occult blood（FOB) is difined normal.

Time frame: through study completion, an average of 1 year

change of hepatic function

The researchers will check the results of ALT and AST. TBil, DBIL, TBA and TP, ALB. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.