Vagus nerve stimulation (VNS) activates neural pathways leading to the release of chemicals that promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear activates neural pathways implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms that are modulated by auricular stimulation and its potential to enhance motor learning.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
4
Visuomotor task training with transcutaneous stimulation targeting landmark that activates biomarker
Human Engineering Research Laboratories
Pittsburgh, Pennsylvania, United States
Precision grip stability (coefficient of variation or root-mean-square error)
The ability to stabilize precision grip according to target force and/or preload force will be quantified by calculating coefficient of variation (CV) or root-mean-square error (RMSE) which characterize variability in relation to mean force or target force.
Time frame: 1 month post training
Force signal composition (Fourier transform)
The force signal oscillates at various frequencies and will be decomposed with a Fourier transform to quantify the relative contribution of higher frequencies.
Time frame: 1 month post training
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.