Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

N/ACompletedNCT05319951

Guangzhou Blood Center6,250 enrolled

Overview

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar \& salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction. However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

6,250

Conditions

Blood Donation

Interventions

Oral Rehydration Salts power (iii)DRUG

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

water with white granulated sugarDIETARY_SUPPLEMENT

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

waterDIETARY_SUPPLEMENT

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study. \- Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations. \-

Locations (1)

Guangzhou Blood Center

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

vasovagal reaction rate

vasovagal reaction rate in three groups

Time frame: 1-3days

Secondary Outcomes

rate of willingness to donate blood again

rate of willingness to donate blood again in three groups

Time frame: 3days

Data from ClinicalTrials.gov

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