data collection based on this study will allow us to collect and calibrate neurophysiological and cognitive data collected from in-ear EEG recordings of the initial baseline/reference population in Swiss healthy individuals that can be used as reference to data collected in other populations, for instance, to be compared with any other similar dataset in the future (e.g., Alzheimer patient cohorts).
There is solid neurophysiological evidence indicating that abnormal brain rhythms during sleep and noradrenergic dysfunction are core components of cognitive decline and AD onset, and their related pathophysiology. Crucially, irregularities in these neurophysiological mechanisms appear to occur in an asymptomatic and pre-symptomatic stage, but their potential to identify susceptibility for triggering neurodegeneration has yet to be established. Thus, the possibility to identify such risk biomarkers in humans will require the acquisition of large-scale data related direct or indirect measurements of these physiological signatures. A possible key source to obtain such large-scale data related to sleep and noradrenergic function is the assessment of electroencephalographic recordings through non-obtrusive, low-cost, and reliable wearable sensors, alongside the use of advanced neuro-computational algorithms that link brain function and behavioral outcomes of LC function via pupilometry measurements.
Study Type
OBSERVATIONAL
Enrollment
120
This is an observational study
ETH Zurich
Zurich, Schweiz, Switzerland
RECRUITINGDensity of slow-wave activity (SWA) readout from in-ear EEG recordings
in-ear EEG will be monitored during 7 nights, the aggregated density of SWA over the 7 nights will be compared in both groups (young vs elderly)
Time frame: 7 nights of at-home recordings
Relative phasic pupilometry responses in exploration vs exploration states in the cognitive task
latent variables of the LC-noradrenergic neuro-computational model based on our cognitive task will indicate the state in wich the participant is (exploration vs exploitation). The relative phasic pupilometry responses in these two states will serve as a proxy of the degree of LC-noradrenergic reaction to these states. The relative reactivity will be compared in both groups (young vs elderly)
Time frame: 1 experimental session
Power changes of wake EEG brain activity in close vs open eyes condition
We will compute the relative changes of EEG power in close vs open eyes. The relative changes will be compared in both groups (young vs elderly)
Time frame: 7 days of at-home recordings
Relative time-frequency decomposition responses in exploration vs exploration states in the cognitive task measured with EEG
We will evaluate the the differences spatio-temporal changes in the power spectrum depending on the state in wich the participant is (exploration vs exploitation) in the cognitive task. The relative changes will be compared in both groups (young vs elderly)
Time frame: 1 experimental session
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