High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.

Ain Shams University60 enrolled

Overview

L-Carnitine supplementation has been shown to boost muscular performance in several studies. In hemodialysis patients with muscular weakness, fatigue, or cramps/aches, after L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms . L-Carnitine was also found to improve the left ventricular ejection fraction (LVEF) in hemodialysis patients with cardiac morbidity who had significantly reduced LVEF in echocardiography before supplementation. Moreover, L-Carnitine has been shown to improve muscular function and exercise performance in athletes in several studies

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Respiratory Failure

Interventions

will receive a maintenance dose of L- carnitine 6 gm/day to keep normal level (normal L-carnitine level is normal 25-50 mmol/L)

L-Carnitine ( high dose)DRUG

will receive a high dose of L- Carnitine 18 gm/day as a continuous intravenous infusion to reach double the normal plasma level

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age from 21 years old or greater * Both genders have respiratory failure either of the primary medical origin or in the post-surgical course. * Not in need of mechanical ventilation Exclusion Criteria: * Renal failure on regular dialysis * Hypothyroidism * Seizures * End-stage liver disease * Mechanical ventilation * History or discovered allergy to L-carnitine, pivampicillin, and other pivalate-conjugated antibiotics.

Locations (2)

Faculty of medicine

Cairo, Egypt

Mona A Ammar

Cairo, Egypt

Outcomes

Primary Outcomes

Ultrasound diaphragmatic function

Diaphragmatic excursion by ultrasound

Time frame: at days 7

Data from ClinicalTrials.gov

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