Meniere's disease is a progressive and debilitating inner ear disease characterised by vertigo and hearing loss. Several studies have linked Menierws disease with lower bone density and lower vitamin D levels. In the current prospective study definite Meniere's patients will be followed over a period of 2 year, during which repetitive measurements of bone density, vitamin D plasma levels, blood pressure as well as hearing and vestibular tests will be made. Results will be compared to healthy controls.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
Measuring vitamin D plasma levels at baseline
Measuring T-score and Z-score of the femur and lumbar spine at baseline
cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured.
hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score.
blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test
The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function.
Measuring vitamin D plasma levels one year after recruitment
Measuring vitamin D plasma levels two years after recruitment
Measuring T-score and Z-score of the femur and lumbar spine one year after recruitment
Measuring T-score and Z-score of the femur and lumbar spine two years after recruitment
cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured one year after recruitment
cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured two years after recruitment
hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score performed one year after recruitment
hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score performed two years after recruitment
blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test. The test will be performed one year after recruitment
blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test. The test will be performed two year after recruitment.
The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function. The test will be performed one year after recruitment.
The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function. The test will be performed two years after recruitment.
Vitamin D plasma levels
Vitamin D plasma levels
Time frame: baseline
Vitamin D plasma levels
Vitamin D plasma levels
Time frame: one year follow up
Vitamin D plasma levels
Vitamin D plasma levels
Time frame: two years follow-up
Z-score and T-score of femur and lumbur spine
DEXA exam - bone density. higher score means better resuls. osteopenia is defined as \<-1 score , osteoporosis is defined as \<-2.5 score
Time frame: baseline
Z-score and T-score of femur and lumbur spine
DEXA exam - bone density. higher score means better resuls. osteopenia is defined as \<-1 score , osteoporosis is defined as \<-2.5 score
Time frame: one year follow up
Z-score and T-score of femur and lumbur spine
DEXA exam - bone density. higher score means better resuls. osteopenia is defined as \<-1 score , osteoporosis is defined as \<-2.5 score
Time frame: two years follow-up
positive ortostatic hypotension
drop of 20mmHg systolic blood pressure or drop of 10mmHG diastolic blood pressure after 3 minutes of standing up. all other results - negetive
Time frame: baseline
positive ortostatic hypotension
drop of 20mmHg systolic blood pressure or drop of 10mmHG diastolic blood pressure after 3 minutes of standing up. all other results - negetive
Time frame: one year follow up
positive ortostatic hypotension
drop of 20mmHg systolic blood pressure or drop of 10mmHG diastolic blood pressure after 3 minutes of standing up. all other results - negetive
Time frame: Two years follow-up
cold pressure - autonomous sympatetic nervous system function - normal vs, inadequete
a rise of less then 15mmHg after the test is considered inadequete function, more then 15hhHg - normal function
Time frame: baseline
cold pressure - autonomous sympatetic nervous system function - normal vs, inadequete
a rise of less then 15mmHg after the test is considered inadequete function, more then 15hhHg - normal function
Time frame: one year follow up
cold pressure - autonomous sympatetic nervous system function - normal vs, inadequete
a rise of less then 15mmHg after the test is considered inadequete function, more then 15hhHg - normal function
Time frame: two years follow-up
ampitude, latency and peak to peak amplitude of the P13 and N23 waves in the cVEMP test
cervical vestibular evoked myogenic potential exam
Time frame: baseline
ampitude, latency and peak to peak amplitude of the P13 and N23 waves in the cVEMP test
cervical vestibular evoked myogenic potential exam
Time frame: one year follow up
ampitude, latency and peak to peak amplitude of the P13 and N23 waves in the cVEMP test
cervical vestibular evoked myogenic potential exam
Time frame: two years follow-up
Hearing level (dB), SRT in dB , descrimination in (%) in the audiology exam
audiology exam
Time frame: baseline
Hearing level (dB), SRT in dB , descrimination in (%) in the audiology exam
audiology exam
Time frame: one year follow up
Hearing level (dB), SRT in dB , descrimination in (%) in the audiology exam
audiology exam
Time frame: two years follow-up
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