Lp(a) With CCTA Assessed Parameters and Clinical Outcomes

Shanghai Zhongshan Hospital378 enrolled

Overview

Lipoprotein(a) \[Lp(a)\] is a risk factor for cardiovascular events, although the underlying mechanism remains unclear. This study evaluated the relationship between Lp(a) and high-risk attributes (HRA) by coronary computed tomography angiography (CCTA) as well as their prognostic value.

Study Type

OBSERVATIONAL

Enrollment

378

Conditions

Coronary Artery Disease

Interventions

Coronary CTADIAGNOSTIC_TEST

Patients receive coroanry CTA at the discretion of the physicians in charge. And parameters including plaque burden, minimal lumen area, diameter stenosis, total plaque volume, high-risk plaque characteristics, fractional flow reserve, pullback pressure gradient, fat attenuation index will be analyzed.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Lp(a) meaured within 1 week of CCTA examination. Exclusion Criteria: * unstable angina pectoris * acute myocardial infarction * New York Heart Association class III-IV heart failure * with a history of bypass surgery * active infection * respiratory failure * chronic kidney disease (estimated glomerular filtration rate \[eGFR\] \<60 ml/min/1.73 m2) * liver dysfunction (liver enzyme \>3 upper reference limit \[URL\] or bilirubin \>2 URL) * malignancy * systemic connective tissue disease * poor CCTA imaging quality not suitable for analysis * other situations not suitable for the study

Locations (1)

Shanghai Zhongshan Hospital

Shanghai, China

RECRUITING