This is a physiopathological case-control, non-interventional, monocentric study of adult patients with lymphangioleiomyomatosis. The controls are patients followed in neurology at the CHU of Tours for a tuberous sclerosis complex without lymphangioleiomyomatosis, the healthy volunteers are women with neither pulmonary nor renal pathology and recruited at the clinical investigation centre of the CHU of Tours.
Study Type
OBSERVATIONAL
Enrollment
19
Urine samples will be collected at home over 24 hours
A urine sample of 20cc will be collected
University hospital
Tours, France
urine cathepsin K proteins levels
comparison of urine cathepsin K protein levels in the 3 groups
Time frame: inclusion visit
urine cathepsin K activity
comparison of urine cathepsin K activity in the 3 groups
Time frame: inclusion visit
urinary quantity of cystatin C
comparison of urine cystacin C quantity in the 3 groups
Time frame: inclusion visit
urinary quantity C and N-telopeptides of type 1 collagen
comparison in the 3 groups
Time frame: inclusion visit
serum level of chondroitin sulphates
measurement in lymphangioleiomyomatosis patients
Time frame: inclusion visit
renal angiolipomas
measurement of the size of renal angiomyolipomas in lymphangioleiomyomatosis patients
Time frame: inclusion visit
FEV1 measurement
most recent FEV1 measurement as % of predicted value in lymphangioleiomyomatosis patients
Time frame: inclusion visit
VEGF-D measurement
most recent measurement of VEGF-D blood levels in lymphangioleiomyomatosis patients
Time frame: inclusion visit
T-score measurement
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T-score measurement of the most recent bone densitometry in lymphangioleiomyomatosis patients
Time frame: inclusion visit