Dexmedetomine vs Dexamethasone in TAB Block for Abdominal Surgries

Ain Shams University45 enrolled

Overview

Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.

A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Anesthesia

Interventions

DexmedetomidineDRUG

adjuvants to 0.25 bupivacaine in TAB block.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2. Exclusion Criteria: * Infection at site of injection. * Patient refusal. * Psychiatric or physical illness that lead to inability to cooperate, speak or read. * Abdominal operations under spinal anesthesia. * History or evidence of coagulopathy. * Known allergies to drugs used . * Preexisting neurological disorders.

Locations (1)

Ain Shams University, Faculty of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

1st time for rescue analgesia

Time to first analgesia requirment(starting from drug injection)

Time frame: first 24 hours post-operatively

Secondary Outcomes

Pain score- Visual Analogue Score (VAS)

It ranges from 0 indicating no pain till 10 indicating severe intolerable pain with variable degrees of ascending pain in between\] was assessed at 0 min (AT PACU), 2hr,6 hr, 12 hr, 18 hr, and 24 hr postoperatively.

Time frame: First 24 hours post-operatively.

Data from ClinicalTrials.gov

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