Sensitivity of Multiparametric MRI in Differentiation Between Muscle Invasive and Non-muscle Invasive Urinary Bladder Cancer

Helwan University30 enrolled

Overview

Differentiation between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) is a cornerstone in the treatment plans.Therefore, this study will try to evaluate the sensitivity and reliability of mpMRI in accurate diagnosis of cancer bladder. Primary objective: to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cancer, Bladder

Interventions

multiparametric MRI on the bladderRADIATION

comparison between mpMRI and histopathology

diagnostic cystoscopy +/- TURBTPROCEDURE

conventional way of diagnosis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All patients diagnosed with NMIBC or MIBC during diagnostic cystoscopy or by any radiologic investigation in the Urology department of Helwan university hospitals without being restricted to age or sex. * All histological types of bladder cancer * Newly diagnosed, recurrent cases, or even patients undergoing follow-up cystoscopy. Exclusion Criteria: * Patients with elevated renal function according to their age as this will be a contraindication to DCE MRI. * Patients with absolute contraindication to MRI (e.g.: metallic prosthesis). * Patients with contraindication to undergo TURBT (e.g.: unfit for surgery).

Locations (1)

Faculty of medicine, Helwan university

Badr, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy.

Time frame: 6 month

Secondary Outcomes

the sensitivity of mpMRI to detect non-visible lesions during follow up cystoscopy while mpMRI reports a positive lesion.

Time frame: 6 month

Data from ClinicalTrials.gov

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