Impaired cognitive function is common among patients with substance use disorder (SUD). This is particularly related to executive functions (EF), which includes abilities like decision-making, consequence analysis and impulse/self-control. EF is recognized as an important determinant of treatment outcome as it is associated with dropout rate, attendance to therapy sessions and absence of relapse following treatment termination. Exercise seem to improve cognitive/executive functions, particularly in individuals with cognitive impairments. Aerobic exercise also affects signaling substances and growth factors known to inhibit neural degeneration, and improves cerebral insulin sensitivity and blood flow, contributing to improved brain function. There is a lack of knowledge regarding how to improve EF in SUD patients, and whether such improvements can benefit other parts of the treatment, such as psychotherapy. Aerobic exercise is a well-recognized and cost-effective intervention for cardiovascular and metabolic health, with promising effects on cognitive/executive functions. A randomized controlled trial will be carried out to investigate the effects of aerobic exercise on EF, molecular markers of neuroplasticity and brain function, and treatment outcome in SUD patients. The investigators expect to achieve new knowledge regarding cognitive impairment among SUD patients and to what extent aerobic exercise can improve cognitive abilities and treatment outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
84
Supervised exercise intervention, three times a week for eight weeks.
The content of TAU is broadly individualized but most often includes various forms of group therapy, psychotherapy, psychoeducation and physical activity. The physical activity schedule for the patients typically includes gym-based exercises, individualized by preference of each patient, and various outdoors activities, four times per week all together.
Lade Behandlingssenter, Blåkors
Trondheim, Trøndelag, Norway
Change in executive function (EF)
Change in executive function assessed with Behavior Rating Inventory of ExecutiveFunction, Adult (BRIEF-A). BRIEF-A is a 75-item standardized questionnaire appraising EFs in real-life situations. It incorporates self-reported cognitive characteristics and collects subjective information about the ability to maintain appropriate control of emotional responses and behavior.
Time frame: 8 weeks
Change in Montreal Cognitive Assessment (MoCA) score
MoCA is a brief neuropsychological assessment to evaluate cognitive function in various domains (i.e. visuospatial/executive abilities, naming, memory, attention, language, abstraction, and orientation). This assessment takes about 10 minutes to perform. Maximum score is 30, but scores from 26 and above is considered normal.
Time frame: 8 weeks
Change in Stroop test score
Stroop is a widely used and validated test evaluate attention and impulse control. This particular test allow 90 seconds to solve as many problems as possible. Each correct answer provides one point, while incorrect answers are subtracted from the total score.
Time frame: 8 weeks
Change in Digit Span test performance
The Digit Span test is an assessment of working memory, using rows of numbers that should be memorized. Each correct answer provides one point with the following sequence being one digit longer than the previous. The test has no limit on time or upper score, but only allows three mistakes before ending.
Time frame: 8 weeks
Altered serum concentration of Brain Derived Neurotrophic Factor (BDNF)
BDNF is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
Time frame: 8 weeks
Altered serum concentration of Klotho
Klotho is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
Time frame: 8 weeks
Altered serum concentration of glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1)
Gpld1 is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
Time frame: 8 weeks
Altered serum concentration of interleukin 6 (IL6)
IL6 is a muscle-secreted protein known to affect neurocognitive/neuroprotective mechanisms
Time frame: 8 weeks
Change in maximal cardiorespiratory fitness
Maximal cardiorespiratory fitness will be measured as oxygen uptake by cardiopulmonary exercise testing on a treadmill, by inclined walking or running on a treadmill
Time frame: 8 weeks
Change in mental distress
Alterations in mental distress will be assessed using the validated brief questionnaire Symptom Checklist-10 (SCL-10)
Time frame: 8 weeks
Change in substance use
Change in substance use will be assessed using a simple self-report questionnaire
Time frame: 8 weeks
Change in substance craving
Change in substance use will be assessed using a simple Visual Analogue Scale ranging from 0 (no craving) to 10 (severe craving)
Time frame: 8 weeks
Change in quality of life
Quality of life will be assessed with a brief version of the World Health Organization Quality of Life assessment
Time frame: 8 weeks
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