Randomized-controlled trial comparing homologous (mRNA vaccine) vs. heterologous (vector vaccine) for third SARS-CoV-2 vaccine dose in kidney transplant recipients not responding to initial prime-boost vaccination with an mRNA vaccine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
Medicial University of Vienna
Vienna, Austria
Seroconversion at 4 weeks
number of patients developing SARS-CoV-2 antibodies at 4 weeks after 3rd vaccination
Time frame: 4 weeks
Seroconversion at 12 weeks
number of patients developing SARS-CoV-2 antibodies at 12 weeks after 3rd vaccination (\> 0.8 BAU/mL)
Time frame: 3 months
SARS-CoV-2 antibody levels at 4 weeks
SARS-CoV-2 antibody levels at 4 weeks after the third vaccination
Time frame: 4 weeks
SARS-CoV-2 antibody levels at 12 weeks
SARS-CoV-2 antibody levels at 12 weeks after the third vaccination
Time frame: 3 months
Seroconversion at 36 weeks
number of patients developing SARS-CoV-2 antibodies at 36 weeks after 3rd vaccination (\> 0.8 BAU/mL)
Time frame: 6 months
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Homologous vaccination