Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Phase 3RecruitingNCT05325580

University of Monastir424 enrolled

Overview

Rate of Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

424

Conditions

Head Pain

Interventions

Magnesium sulfateDRUG

magnesium group 1g paracetamol + 20 min infusion of 2 g magnesium in 150 ml of saline serum and Placebo Group 1g paracetamol + 20 min infusion of 150 ml of saline serum

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * informed consent * age \>18 years * Acute non-traumatic acute headaches * patients treated in ED * Magnesium sulfate and aspirin administered intravenously (IV) Exclusion Criteria: * Current regular use of analgesics, anticonvulsants or antidepressants * Renal disorder with a low glomerular filtration rate (\<60 ml/min) * Neuromuscular disorder * Pregnant woman * Contrindication * Allergy to NSAID * Traumatic Headache * Chronic headache ( headache occurring at least 15 days per month for at least 3 months) * Hemodynamic instability

Locations (1)

University of Monasrtir

Monastir, Tunisia

RECRUITING

Outcomes

Primary Outcomes

Intravenous Magnesium Sulfate to Treat Non -Traumatic Acute Headaches in the Emergency Department

Patients with Non -Traumatic Acute Headaches in the Emergency Department recived 1g paracetamol + 20 min infusion of 2g magnesium

Time frame: 1day

Secondary Outcomes

Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Patients with Non -Traumatic Acute Headaches in the Emergency Department received 1g paracetamol + 20 min infusion of saline serum

Time frame: 1 day

Central Contacts

Semir Nouira, Professor

CONTACT

7310600 semir.nouira@rns.tn

Khaoula Bel Haj Ali, MD

CONTACT

7310600 belhajalikhaoula@yahoo.fr

Data from ClinicalTrials.gov

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