decipher the role of microbiota in glycemic response change after bariatric surgery
Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks. Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations. The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.
Study Type
OBSERVATIONAL
Enrollment
120
participants undergoing sleeve gastrectomy surgery
participants undergoing gastric bypass surgery
cholecystectomy
Weizmann Institute of Science
Rehovot, Israel
RECRUITINGSouraski medical center
Tel Aviv, Israel
RECRUITINGGlycemic response
The glycemic response will be measured by taking a blood test (glucose) after 12 hours fast and a second blood test (glucose) after an OGTT(oral glucose tolerance test) of 50 g glucose
Time frame: up to 4 years
microbiota composition
The microbiota composition will be assessed using the stool samples of the participants.
Time frame: up to 4 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Collecting a sample of an unidentified healthy pancreas to extract insulin-secreting beta cells from the sample