HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

Future University in Egypt14 enrolled

Overview

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals. The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

Study Type

OBSERVATIONAL

Enrollment

Conditions

Peri-Implantitis

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Medically free patients * Individuals with restored implants placed one year or more before study enrollment * Both genders * Age range 20-50 years old Exclusion Criteria: * Pregnant Females * Lactating females

Locations (1)

Faculty of oral and dental medicine,FUE, Cairo,Egypt

Cairo, Egypt

Outcomes

Primary Outcomes

Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid

Markers collected using periopaper strips

Time frame: Baseline

Data from ClinicalTrials.gov

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