This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary syndrome) undergoing PGT-A (preimplantation genetic testing for aneuploidy). Infertile women with PCOS will be recruited for study after explanation and counseling if they fulfill the inclusion criteria and do not have the exclusion criteria. Eligible women will be randomised into one of the two groups: Antagonist group: Women will receive antagonist once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger. PPOS group: Women will receive oral MPA (medroxyprogesterone acetate)10mg qd from Day 3 till the day of ovulation trigger. The primary outcome is the euploidy rate of blastocysts.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
204
GnRH antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger
oral MPA 10mg qd from Day 3 of ovarian stimulation till the day of ovulation trigger.
euploidy rate
euploidy rate of blastocysts
Time frame: 1 month after oocyte retrieval
live birth rate
deliveries ≥22 weeks gestation with heartbeat and breath of the first frozen embryo transfer
Time frame: 1 year after embryo transfer
cumulative live birth rate
cumulative live birth within 6 months of randomization
Time frame: 1 year after embryo transfer
ongoing pregnancy
a viable pregnancy beyond 12 weeks' gestation of the first frozen embryo transfer
Time frame: 12 weeks' gestation
number of oocytes retrieved
number of oocytes retrieved
Time frame: 1 day after oocyte retrieval
OHSS(ovarian hyperstimulation syndrome)
Moderate or severe ovarian hyperstimulation syndrome.Ovarian hyperstimulation syndrome (OHSS) is diagnosed and classified according to the Royal College of Obstetricians and Gynaecologists guideline. Green-top guideline No.5. Ovarian hyperstimulation syndrome. https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg5/ (accessed 26 Feb 2016).
Time frame: 1 month after ovarian stimulation
birthweight of newborns
birthweight of newborns
Time frame: 1 year after embryo transfer
XIAOXI SUN, PHD
CONTACT
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