Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.
This is a single-center, prospective, cohort study. This study will include approximate 369 post-liver transplantation patients with renal impairment and have received renal biopsy. Demographic characteristics, medical history, etiology of liver failure, concomitant medications, baseline laboratory parameters, etc., will be recorded. All participants will receive standard treatment by hepatologists and nephrologists based on the pathological results. All participants will be followed up for 96 weeks. Renal function, concomitant medications, and other laboratory parameters, etc., will be obtained.
Study Type
OBSERVATIONAL
Enrollment
369
Standard percutaneous biopsy has been performed in all participants. Modification of treatment will be jointly decided by hepatologists and nephrologists based on the pathological results. All participants will be followed up for 96 weeks.
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
NOT_YET_RECRUITINGRen Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
RECRUITINGProgression of renal function
Describe the cumulative incidence of renal function progression in post-liver transplantation patients with renal impairment after renal biopsy. Renal function progression is defined as a composite of end-starge renal disease(ESRD) or \>100% increase of serum creatinine(Scr) or \>50% per year decline of estimated glomerular filtration rate (eGFR)
Time frame: 96 weeks
Risk factors of renal function deterioration in post-liver transplantation with renal impairment after renal biopsy
Investigate the risk factors of renal function deterioration in post-liver transplantation patients with renal impairment after renal biospy. Renal function deterioration is defined as a composite of ESRD or \>100% increase of Scr or \>50% per year decline of eGFR.
Time frame: 96 weeks
Pathology of kidney disease
Describe the pathology of kidney disease in post-liver transplantation patients with renal impairment.
Time frame: 96 weeks
Patient survival in post-liver transplantation patients with renal impairment after renal biopsy
Describe the patient survival rate in post-liver transplantation patients with renal impairment after renal biopsy.
Time frame: 96 weeks
Kidney survival in post-liver transplantation patients with renal impairment after renal biopsy
Describe the kidney survival rate in post-liver transplantation patients with renal impairment.
Time frame: 96 weeks
Remission of renal disease in post-liver transplantation patients with renal impairment after renal bisopy.
To describe the remission rate of renal disease in post-liver transplantation patients with renal impairment after renal biopsy. Remission is defined as 24-hour proteinuria decrease to \<0.3g/24h or \<50%of baseline, with stable kidney function(eGFR decrease less than 15%)
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Time frame: 96 weeks
Effect of acute liver failure before liver trasplatation on renal impairment
Investigate the effect of acute liver failure before liver trasplatation on renal impairment with subgroup analysis.
Time frame: 96 weeks