Targeting Microbiota in Female Overactive Bladder Syndrome

Medical University of Vienna100 enrolled

Overview

The aim of this study is to compare the urinary viral microbiome and bacterial microbiome between overactive bladder syndrome (OAB) patients and healthy controls in order to determine a possible alteration in the urinary microbiome which may predispose women for OAB, and also in order to determine a possible influence of the urinary viral microbiome on the urinary bacterial microbiome which may predispose the individual to OAB. Furthermore, we aim to compare the urinary bacterial microbiome to the vaginal, rectal, urethral and salivary bacterial microbiome within the same individual and between the two groups in order to determine a possible route of colonization of the urinary bladder.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Microbiota Urinary Bladder, Overactive

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (case group): * symptoms of overactive bladder (urgency with or without urinary leakage, usually with frequency and nocturia) Exclusion Criteria (case group): * Pregnant or lactating females * Neurological conditions (such as MS, Parkinson, spinal cord injury, stroke..) * Pelvic Organ Prolapse (stage ≥ 3) * Lower Urinary Tract surgery within past 6 months * Known history of interstitial cystitis or pain associated with OAB * Recurrent urinary tract infections \> 3/year * Acute urinary tract infection * Urinary retention (with or without required self- catheterization) * Stress urinary incontinence or mixed urinary incontinence * Bladder cancer * Renal insufficiency * Urinary tract stones Inclusion Criteria (control group): without symptoms of overactive bladder or any other form of lower urinary tract symptoms * Age-matched to case group (+/- 5 years) * BMI-matched to case group (18,5- 24,9 kg/m2 normal weight; 25- 29,9 kg/m2 overweight; 30- 34,9 kg/m2 obesity grade I) Exclusion criteria (control group): As case group plus any form of lower urinary tract symptoms including OAB

Targeting Microbiota in Female Overactive Bladder Syndrome

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts