Comparing the Effects of Exercise on the Structure and Function of Fat Tissue

University of Michigan45 enrolled

Overview

Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Adiposity

Interventions

Oral Glucose Tolerance TestDIAGNOSTIC_TEST

Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18-40 years old * Body Mass Index: 23-35 kg/m2 * Women must have regularly occurring menses and must be premenopausal Exclusion Criteria: * Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism, or inflammation * Weight instability ≥ ± 6 pounds in the last 6 months * Tobacco or e-cigarette users * Women must not be pregnant or actively lactating * Blood pressure \> 140/90 mmHg

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Blood Glucose Level

mg/dL

Time frame: 2 hours at Experimental Trial

Adipose tissue fibrosis

Pico-sirius Red stain (percent stained)

Time frame: baseline

Data from ClinicalTrials.gov

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